The majority of miRNAs were chosen due to their high expression levels in breast milk, or the fact that they are targets of leptin, adiponectin, or their receptors (miR-30a, miR-146b, miR-17, miR-let-7a, and miR-222), or are somehow related to adipogenesis and obesity development (miR-30b, miR-103, miR-148a, miR-17, miR-let-7a, miR-222, miR-378, miR-130a, miR-128, miR-27b, miR-34a, miR-484, miR-642a, miR-30c, miR-448, miR-302b, and miR-224). The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.