F2 and thrombophilia: Medical history revealed a high thromboembolic burden, as six patients had a documented history of pulmonary embolism (PE), and two were found to have established inherited thrombophilia (one patient homozygous for the prothrombin gene 20210A mutation, rs1799963, and one patient heterozygous for factor V Leiden, rs6025, Supplementary Table S1).