In contrast, the X-inactive specific transcript lncRNA XIST is markedly upregulated in DN and sponges the anti-fibrotic miR-93-5p, thereby de-repressing Cyclin-Dependent Kinase Inhibitor 1A (CDKN1A) and exacerbating renal fibrosis [65]. The gene discussed is CDKN1A; the disease is renal fibrosis.