For example, lncRNA TUG1 (taurine upregulated gene 1) is downregulated in DN, leading to mitochondrial dysfunction in podocytes; transgenic overexpression of TUG1 in podocytes of diabetic mice preserved mitochondrial biogenesis via PGC-1α and protected against nephropathy [65]. The gene discussed is TUG1; the disease is liver dysplastic nodule.