Moreover, in one of the validated cancer predisposition genes, APC, deep intronic germline variants such as c.1408+731C>T (p.Gly471fs), c.1408+735A>T (p.Gly471fs), c.1408+729A>G (p.Gly471fs), and c.532-941G>A (p.Phe178fs) have been predicted to be pathogenic—although these do not appear to be major contributors to colorectal polyposis in the Dutch population [29,30]. This evidence concerns the gene APC and polyp of large intestine.