Numerous studies have confirmed the interaction between the FTO genotype and an active lifestyle, with physical activity shown to attenuate the effect of the rs9939609 A allele on BMI by up to 30–47% [398,402], as well as reduce the risk of associated comorbidities such as type 2 diabetes, hypertension, and all-cause mortality [402,403,404]. The gene discussed is FTO; the disease is type 2 diabetes mellitus.