For instance, the identification of FTO or PPARG risk alleles could guide early lifestyle interventions in individuals at high risk for obesity or type 2 diabetes [402,403,413], while variants in COL1A1 or IL6 may allow the identification of increased susceptibility to tendon or ligament injuries [329,350,362]. This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.