They divided the founded polymorphisms into hyperresponsive variants IL1B-3954-T, TNFA-308-A, IL6-174-C, and hyporesponsive ones IL10-592-C and TLR4-299-G; the first ones were higher in periodontitis, and the second ones were more frequent in gingivitis, suggesting risk and protective roles, respectively. Here, TLR4 is linked to gingivitis.