In a murine model of CRS type 2 induced by surgical myocardial infarction, Hao et al. demonstrated an increase in circulating FGF23 at 12 weeks, as well as upregulation of genes for FGF23 and FGFR4 in cardiac tissue and an upregulation of FGFR4 genes in renal tissue [52]. Here, FGF23 is linked to myocardial infarction.