IGHE and asthma: Its single nucleotide polymorphisms (e.g., rs2251746 and rs2427837) can impair transcription factor binding (e.g., GATA-1), thereby reducing FCER1A promoter activity and FcεRIα receptor expression, which consequently modulates IgE levels [31,32] and significantly elevates the risk of developing allergic disorders such as asthma and atopic dermatitis [36].