Acute myeloid leukemia with CBFB::MYH11 fusion (CBFB::MYH11 AML) is a subgroup of core binding factor AML (CBF-AML), typically resulting from either inv(16) (p13.1q22) or t(16; 16) (p13.1; q22), and accounts for approximately 12% of all pediatric AML cases [1]. Here, CBFB is linked to acute myeloid leukemia.