RUNX1 and hematologic disorder: Furthermore, impaired RUNX1 function disrupts the normal differentiation and proliferation of hematopoietic stem and progenitor cells, thereby increasing the risk of developing hematologic malignancies, particularly myeloid leukemias [30,31,32], while SON is implicated in Zhu–Tokita–Takenouchi–Kim syndrome [11], which is a rare neurodevelopmental disorder characterized by a heterogeneous spectrum of phenotypic and clinical features [4,6].