PTPRC and periventricular leukomalacia: In PVL-OSCC cases, moderate to strong membranous/cytoplasmic staining of CD45 was observed in focal areas of connective tissue cells between the neoplastic epithelial islands, while mild expression was observed in few intraepithelial cells (Figure 5B), with 6/10 PVL-OSCC cases presenting a final score of 1 to 3 (Figure 2, Table S2).