For example, fumarate hydratase was significantly downregulated in HLRCC fibroids compared to wild-type fibroids (measured as fold-change compared to matched-myometrium; p < 0.02), while several glycolysis enzymes were significantly upregulated, including hexokinase 1 (p < 0.01), phosphofructokinase (p < 0.01), aldolase (p < 0.01), triosephosphate isomerase (p < 0.01), phosphoglycerate kinase (p < 0.01), enolase, and pyruvate kinase (p < 0.01). This evidence concerns the gene FH and hereditary leiomyomatosis and renal cell cancer.