Upon validation with real-time reverse-transcriptase PCR to quantitatively measure alterations in glycolysis enzymes and fumarate hydratase, results confirmed the microarray findings and showed that multiple glycolysis enzymes were overexpressed in HLRCC fibroids but not in nonsyndromic fibroids relative to patient-matched myometrium [32]. The gene discussed is FH; the disease is hereditary leiomyomatosis and renal cell cancer.