This yields testable predictions: H1—mTOR-axis genes show distinct alteration patterns across tumor types (shared vs. tumor-specific); H2—non-mutated genes proximal to the mTOR core contribute via “guilty-by-association” and can be nominated by network propagation; H3—elevated expression of translational hubs aligns with mTOR dependency and specific mutation/SCNA contexts. The gene discussed is MTOR; the disease is neoplasm.