MTOR and colorectal adenocarcinoma: UniProtKB indicated higher testis expression and primordial germ-cell over-expression for MTOR, and catalogued cancer-linked missense variants—A8S (rs748801456; lung large cell carcinoma), M2011V (rs2100412651; ovarian mucinous carcinoma), S2215Y (rs587777894; colorectal adenocarcinoma), L2220F (rs2100381099; renal cell carcinoma), V2406A (rs2100316251; renal cell carcinoma)—of which S2215Y and L2220F lie within/near the kinase-domain region, providing a plausible structural basis for altered catalytic output (Table 1).