RYR1 and Malignant hyperthermia: To date, more than 1000 distinct RYR1 variants have been reported (HGMD; https://www.hgmd.cf.ac.uk/ (accessed on 13 February 2025) and LOVD; https://databases.lovd.nl/shared/genes/RYR1, (accessed on 13 February 2025)), yet only 72 have been classified as diagnostic mutations by the European Malignant Hyperthermia Group (EMHG; https://www.emhg.org/diagnostic-mutations (accessed on 13 February 2025)).