Similar mechanisms are well-documented in Hutchinson–Gilford progeria syndrome (HGPS), in which the LMNA c.1824C>T (p.G608G) variant causes aberrant splicing and accumulation of the toxic lamin A isoform, progerin, leading to progressive vascular calcification and atherosclerosis [15]. This evidence concerns the gene LMNA and Hutchinson-Gilford progeria syndrome.