Under normal conditions, bilirubin circulates in the bloodstream bound to albumin; however, in neonates with hereditary hemolytic anemia (HHA), a rapid rise in unconjugated bilirubin level may exceed the binding capacity of albumin, allowing free bilirubin to cross the blood–brain barrier and increase the risk of neurotoxicity [2]. The gene discussed is ALB; the disease is Congenital hemolytic anemia.