ABCA1 and atherosclerosis: For example, a study in vivo in murine blood cells has demonstrated that NOX enzymes (NOX 2/4), are a major contributor to ROS production, leading to the downregulation of transporters such as ABCA1 and ABCG1, and induce the accumulation of oxidized LDL, especially in areas susceptible to atherosclerosis [91,92,93].