Furthermore, investigations into the significance of RSPO2-regulated lymphangiogenesis in atherosclerosis revealed that blockade of LGR4-mediated signaling employing the perivascular application of RSPO2’s decoy receptor (LGR4 extracellular domain) promotes arterial lymphatic vessel density, increases arterial cholesterol drainage and reduces atherosclerosis (Figure 3A). The gene discussed is LGR4; the disease is atherosclerosis.