RSPO2 and atherosclerosis: Furthermore, investigations into the significance of RSPO2-regulated lymphangiogenesis in atherosclerosis revealed that blockade of LGR4-mediated signaling employing the perivascular application of RSPO2’s decoy receptor (LGR4 extracellular domain) promotes arterial lymphatic vessel density, increases arterial cholesterol drainage and reduces atherosclerosis (Figure 3A).