In this study, we employed both in vitro and in vivo models to evaluate whether cepharanthine can suppress cell viability and induce mitochondrial apoptosis in cervical cancer cells (CaSki, HeLa, and C33A) through AMPK/p53 pathway activation and Nrf2/Keap1 pathway modulation (Figure 11). This evidence concerns the gene KEAP1 and cervical cancer.