SOD1 and colorectal cancer: Bai et al. [40] and Li et al. [41] reported that cepharanthine can destroy mitochondria, thereby inhibiting the antioxidative function of Nrf2 to promote ROS generation and weaken the antioxidant agents catalase (CAT) and superoxide dismutase (SOD) in lung and colorectal cancers (SW480 and SW620).