In a large Czech cohort including 832 CRC cases and 705 controls, three single nucleotides polymorphisms, namely rs713041 (Gpx4), rs7579 (Sepp1), rs34713741 (selenoprotein S) were significantly associated with a 33–68% increased risk of CRC, and the associations remained significant after adjustment for lifestyle confounders and sex [183]. The gene discussed is SELENOP; the disease is colorectal carcinoma.