Unlike GPX1, GPX2 is selectively expressed in the gastrointestinal tract, where its upregulation has been observed both in experimental colitis models and in patients with IBD, suggesting that H2O2 plays a pivotal role in the inflammatory process underlying IBD and that GPX2 induction serves as a compensatory response to oxidative stress [165,169,170,171]. This evidence concerns the gene GPX2 and irritable bowel syndrome.