This study investigated SVHRSP’s therapeutic potential in dextran sodium sulfate (DSS)-induced chronic colitis, aiming to validate its peripheral anti-inflammatory efficacy and to elucidate its dependence on α7nAChR-Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling. The gene discussed is JAK2; the disease is Chronic colitis.