In Figure 7, in CRSsNP, the cluster genes, like TXNRD1, PRDX5, TXN, GPX2, GCLC, SLC7A11, formed a highly interconnected and tight core network, indicating strong functional interdependence, especially within antioxidant defense pathways including the thioredoxin system (TXN, TXNRD1), peroxiredoxin system (PRDX5), and GSH system (GCLC, GPX2, SLC7A11) (highlighted by a circle). The gene discussed is PRDX5; the disease is chronic rhinosinusitis without nasal polyps.