CYBB and chronic rhinosinusitis with nasal polyps: Conversely, in CRSwNP, the core triangle cluster of PTGS2, MPO, and CYBB (NOX2) with FTH1 at the top indicates centrality in ROS/RNS generation (CYBB via NADPH oxidase and PTGS2) and neutrophil- and prooxidant-mediated microbial killing (MPO) with iron metabolism (FTH1) bridging the gap, suggesting “a prooxidant-inflammatory axis” (highlighted by a circle).