Interestingly, Shinnoh et al. demonstrated that Clostridium butyricum MIYAIRI 588 exerted antitumor effects in a mouse BC model by stimulating neutrophils to release TRAIL (TNF-related apoptosis-inducing ligand) through the activation of MMP-8 (matrix metalloproteinase-8). Here, TNFSF10 is linked to breast cancer.