SIRT1 and atherosclerosis: Furthermore, in human aortic endothelial cells and serum from ApoE−/− mice, Mito-Esc activated the metabolic and stress-sensing autophagy regulator, SIRT1, altered miR-19b and miR-30c and significantly inhibited plasminogen activator inhibitor-1 (PAI-1), a key mediator of atherosclerosis [200].