CREBBP and congestive heart failure: Similarly, another potent Nrf2 activator, bardoxolone methyl, promoted Nrf2 binding to the transcriptional co-activator CREB-binding protein (CBP) and increased Nrf2 downstream targets, including NQO-1, HO-1, catalase and the glutamate-cysteine ligase catalytic (GCLC) subunit, consequently attenuating myocardial inflammation and improving cardiac function in rats with chronic heart failure [282].