Thus, mtROS can activate the NLRP3-dependent pyroptosis pathway by inducing the oxidation of GSDMD, which damages cardiomyocytes and myocardial tissue, leading to various cardiovascular conditions, including cardiac hypertrophy, atherosclerosis, and myocardial reperfusion injury [113,114,115]. The gene discussed is NLRP3; the disease is atherosclerosis.