MAPK1 and cholangiocarcinoma: Protein–protein interaction (PPI) network analysis of the overlapping targets between tiliacorinine and cholangiocarcinoma identified SRC, HIF1A, HSP90AA1, NFKB1, MTOR, MMP9, MMP2, PIK3CA, ICAM1, and MAPK1 as central hub genes (Figure 2C).