THBD and cardiovascular disorder: Olivares-Caro et al. (2023) [7] indicated that reducing the risk of cardiovascular disease caused by a high-fat diet, where through the study of mouse plasma metabolome after chronic consumption of calafate extract, changes were evident in plasma biomarkers related to CVD, specifically thrombomodulin (−24%), adiponectin (+68%), soluble endothelial leukocyte adhesion molecule-1 (sE-selectin) (−34%), soluble intercellular adhesion molecule-1 (sICAM-1) (−24%), and pro-matrix metalloproteinase-9 (proMMP-9) (−31%) levels.