For the DLMs in the comparison of D16 vs. D0, the enriched KEGG pathways primarily include insulin secretion, regulation of lipolysis in adipocytes, lipid and atherosclerosis, cholesterol metabolism, vitamin digestion and absorption, fat digestion and absorption, thermogenesis, and glycerophospholipid metabolism (Figure 8D; Table S7). Here, INS is linked to atherosclerosis.