Future investigation on EV-mediated protein/miRNA export in mediating protection against cancer metastasis to skeletal muscle is therefore needed, not just for decorin (identified here in EVs) and previously recognised as a tumour suppressor, but other proteins enriched in C2C12 myocytes involved in lysosomal and mitochondrial pathways, including cathepsins and Bcl-2 proteins. This evidence concerns the gene DCN and cancer.