Subsequent step-wise multivariate regression distilled the model to four independent predictors—NPM1 (HR = 1.42), RUNX2 (HR = 1.25), TET1 (HR = 1.41), and TIA1 (HR = 0.67)—thereby establishing a concise LLPS-related signature for risk stratification in bladder cancer (Figure 1D). Here, RUNX2 is linked to urinary bladder cancer.