Although currently unexploited, the plethora of histone PTMs involved in DNA repair and their respective HMEs, such as methyltransferases, acetyltransferases, (writers) and demethylases, deacetylases (erasers), as well as bromodomains and chromodomains (readers), present great potential for neurodegenerative disease treatment. Here, MBD2 is linked to neurodegenerative disease.