EGFR and silicosis: Their findings suggested that AAP can attenuate the secretion of epidermal growth factor receptor (EGFR) ligands (such as TGF-α, EGF, and AREG) and modulate signaling pathways between the gut and lungs, effectively inhibiting the EGFR/JNK signaling pathway in lung tissues, thereby conferring therapeutic effects against silicosis [73].