Under inflammatory conditions, such as IBD (inflammatory bowel disease), activated GSK3β enhances the NF-κB (nuclear factor kappa B) and MAPK (mitogen-activated protein kinase) signaling pathways, promoting the secretion of pro-inflammatory cytokines like IL-6 (interleukin-6) and TNF-α (tumor necrosis factor-alpha) and exacerbating intestinal inflammation [31]. The gene discussed is NFKB1; the disease is inflammatory bowel disease.