Table 3 summarizes the role of SIRT1 in HR+ and HER2+ breast cancer. These findings demonstrate the complex and context-dependent role of SIRT1 in breast cancer. While it often promotes tumor progression in HR+ and HER2+ subtypes, its dual role under certain circumstances suggests that therapeutic strategies targeting SIRT1 should be carefully tailored to the specific molecular characteristics of the tumor (Table 3). The gene discussed is SIRT1; the disease is breast carcinoma.