ERBB2 and breast cancer: Table 3 summarizes the role of SIRT1 in HR+ and HER2+ breast cancer. These findings demonstrate the complex and context-dependent role of SIRT1 in breast cancer. While it often promotes tumor progression in HR+ and HER2+ subtypes, its dual role under certain circumstances suggests that therapeutic strategies targeting SIRT1 should be carefully tailored to the specific molecular characteristics of the tumor (Table 3).