Table 2 summarizes the described non-histone proteins deacetylated by SIRT1 and their activities if SIRT1 is activated or suppressed, and Supplementary Table S2 demonstrates the wide range of non-histone deacetylation targets, which are involved in regulating various cellular processes, including tumor suppression, metabolism, stress response, DNA repair, and circadian rhythm. This evidence concerns the gene SIRT1 and neoplasm.