These M2-like macrophages promote tumor growth and metastasis through various mechanisms, including the secretion of immunosuppressive cytokines (e.g., IL-10 and TGFβ), upregulation of immune checkpoints, promotion of angiogenesis, and remodeling of the extracellular matrix to facilitate tumor invasion [49,50,51]. This evidence concerns the gene TGFB1 and neoplasm.