Recurrence is also related to the tumor’s intrinsic and acquired chemoresistance mechanisms, including the expression of DNA repair enzymes (e.g., O-6-methylguanine-DNA methyltransferase, MGMT), altered drug efflux systems, metabolic reprogramming, and the survival of therapy-resistant glioblastoma stem cells (GSCs), which play a key role in tumor growth and in therapeutic resistance, exhibiting low responsiveness to both chemotherapies and radiotherapies, which further decreases following repeated chemoradiation treatments [4,9,10,11]. The gene discussed is MGMT; the disease is neoplasm.