The therapeutic effects of MSSA are mediated through multiple mechanisms: (1) enhancement of rCBF and reduction of cerebral infarction areas, which are critical for maintaining brain function and promoting recovery; (2) modulation of H‐reflex properties, a key indicator of neural excitability and reflex regulation; and (3) up regulation of 5‐HT2AR and KCC2 expression in the spinal lumbar enlargement. Here, SLC12A5 is linked to brain infarction.