C9orf72 deficiency can drive lysosomal accumulation and age-related neuroinflammation in macrophages and microglia [277], highlighting a potential role of C9orf72 in the regulation of immunosenescence in ALS/FTD. However, the mechanistic pathways linking immune cell senescence to neurodegeneration in ALS/FTD are not fully elucidated. The gene discussed is C9orf72; the disease is frontotemporal dementia.