Our study found that AK5 SNPs are not in linkage disequilibrium with the APOE loci, indicating that AK5 can serve as a significant genetic marker independently of APOE. Genetic testing for both APOE and AK5, particularly the rs59556669 and rs75224576 SNPs, may help to refine our understanding of AD susceptibility. This evidence concerns the gene APOE and Alzheimer disease.