TMEM106B and depressive symptom measurement: For TMEM106B (Transmembrane Protein 106B), a locus previously linked to both depression and coronary artery disease [23], we observed genome-wide significance in the LGF, strong association with comorbid traits (p-value = 8.0e-10) but only marginal evidence in CVD traits (p-value = 1.1e-03).