MAP2K5 and atherosclerosis: MAP2K5, a component of the MAPK/ERK5 signaling pathway that influences endothelial dysfunction and atherosclerosis [25, 26], reached genome-wide significance in the LGF and strong comorbid signal (p-value = 3.1e-13) but showed only nominal evidence in CVD traits (p-value = 5.3e-03).