GOT2 and viral infectious disease: In cases of virus infection, Siniperca chuatsi rhabdovirus (SCRV) and infectious spleen and kidney necrosis virus (ISKNV) have been shown to upregulate the expression of GOT1, GOT2, MDH1 and MDH2, thereby supplying substrates for asparagine biosynthesis and promoting virus replication [21, 22].