Alport syndrome is a genetic condition characterized by kidney disease, loss of hearing, and eye abnormalities, due to a mutation in the genes encoding alpha-3, alpha-4, and alpha-5 of type IV collagen (COL4A3, COL4A4, COL4A5) or collagen 4 α345 network [2]. The gene discussed is COL4A4; the disease is Alport syndrome.