After adjusting for hypertension, HbA1c, ApoB, and BNP (primary model), both muscle volume (OR per 1 SD = 0.60, P < 0.01) and muscle density (OR per 1 SD = 0.65, P = 0.016) remained independently associated with lower odds of CVEs (Table 3; Fig. 1). The gene discussed is NPPB; the disease is hypertensive disorder.