Nonetheless, checkpoint blockade still resulted in significant downregulation of TCF-1 and SLAMF6 (Extended Data Fig. 10a–c), reduced SLAMF6+ TSL numbers (Extended Data Fig. 10d,e), reduced imputed TCR affinity (Extended Data Fig. 10f,g), as well as a similar partial inhibition of tumour growth as seen in non-CD4-depleted mice (Extended Data Fig. 10h). The gene discussed is SLAMF6; the disease is neoplasm.