We focused on proteins that have been linked to both brain aging and AD in our analysis (NEFL, GFAP, KLK6, BCAN, SYT1 and CNTN1), as well as proteins potentially implicated in AD pathology (MAPT (tau), APP and APPL2) or prioritized in previous studies (GDF15 (ref. 31) and NRXN3 (ref. 3)). The gene discussed is NRXN3; the disease is Alzheimer disease.