Among the top 20 proteins in the brain aging clock, those associated with at least two dementia phenotypes included glial fibrillary acidic protein (GFAP), neurofilament light chain polypeptide (NEFL), brevican (BCAN), kallikrein-6 (KLK6) and synaptotagmin-1 (SYT1). The gene discussed is NEFL; the disease is dementia.