APOE and dementia: The brain age gap had a strong independent association with dementia (HR = 1.88, P = 1.34 × 10−17), additive to the effects of other biomarkers such as the APOE4 genotype (HR = 1.70, P = 4.37 × 10−4), PRS (HR = 1.48 per 1-s.d.