For example, in disorders of network hyperexcitability such as epilepsy, which may involve an imbalance where excitatory asynchronous release is enhanced or tonic inhibitory asynchronous release is impaired, compounds that selectively dampen the function of calcium sensors like Syt-7 or Doc2α, or enhance the clamping function of Syt-1, could provide novel therapeutic benefits. Here, SYT1 is linked to epilepsy.