TARDBP and proteostasis deficiencies: Proteinopathies associated with α-synuclein (e.g., Lewy bodies (LB) spectrum disorders), TDP-43 (e.g., frontotemporal lobar degeneration (FTLD-TDP43), limbic-predominant age-related TDP-43 encephalopathy-neuropathologic change (LATE-NC)), [29, 30, 45, 46] non-AD tau (e.g., FTLD-tau, argyrophilic grain disease (AGD)), [58] as well as vascular brain injury (VBI) [3] commonly coexist with ADNC as postmortem findings [12, 31, 33].