Although we detected ACE2, TMPRSS2, CAS-3, and SARS-CoV-2 nucleocapsid protein in the outermost layer of plucked human HFs—suggesting a possible entry route for the virus into follicular epithelial cells—only a subset of COVID-19 patients develop symptoms of telogen effluvium (TE). Here, ACE2 is linked to Hand-foot syndrome.