ATXN2 and amyotrophic lateral sclerosis: Though there is no curative treatment for SCA2 yet, Ataxin-2 abundance-lowering strategies, based on small chemical compounds33–35, antisense oligonucleotides36,37 or Cas13 CRISPR effectors38 against Atxn2 mRNA, and also on pharmacological autophagy enhancement39, proved successful in experiments conducted in murine SCA2/ALS models.