NLRP3 expression is increased in bone marrow cells from MPN patients and NLRP3 inflammasome activation is enhanced in response to various stimuli in monocytes from MPN patients, human JAK2V617F mutant iPSC-derived and murine bone marrow-derived macrophages (BMDM)17–19. Here, NLRP3 is linked to myeloproliferative neoplasm.