Similarly, significant enhancement of PCBP2 protein level correlated with neuronal PCBP2 condensation in both the cortex and hippocampus of 5×FAD mice (Fig. 1c–e and Supplementary Fig. 1a, b) and APP/PS1 mice (Supplementary Fig. 1c–e), two animal models of AD. Here, PSEN1 is linked to Alzheimer disease.