APP and Alzheimer disease: Under normal condition, small and irregular PCBP2 granules were evenly distributed in nucleus of SH-SY5Y cells, whereas the enlarged PCBP2 clusters were localized to the cytoplasm, either in a cellular AD model of SH-SY5Y cells that stably overexpress APP (SH-SY5Y-APP), or in SH-SY5Y cells treated with SG inducer arsenite (Ars) (Fig. 1f).